{"id":674,"date":"2022-01-16T22:43:19","date_gmt":"2022-01-16T13:43:19","guid":{"rendered":"https:\/\/obgyn.jp\/?p=674"},"modified":"2024-03-04T00:04:11","modified_gmt":"2024-03-03T15:04:11","slug":"tc-bev","status":"publish","type":"post","link":"https:\/\/obgyn.jp\/?p=674","title":{"rendered":"TC\uff08PTX + CBDCA\uff09+ Bev \u7642\u6cd5 \u30ec\u30b8\u30e1\u30f3"},"content":{"rendered":"\n
\n

\u25c6\u5a66\u4eba\u79d1\u3067\u306e\u4fdd\u967a\u9069\u7528<\/h3>\n\n\n\n

\u5375\u5de3\u764c\u3001\u5b50\u5bae\u981a\u764c\u3002<\/h4>\n\n\n\n

\u25c6Emetic risk\uff1amoderate<\/a> <\/h3>\n\n\n\n

\u25c6\u6e1b\u91cf\u57fa\u6e96<\/h3>\n\n\n\n

\u6709\u5bb3\u4e8b\u8c61\u306e\u51fa\u73fe\u72b6\u6cc1\u306b\u3088\u308a\u300120%\u6e1b\u91cf\u3059\u308b\u3002Grade 2\u306e\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u304c\u307f\u3089\u308c\u305f\u5834\u5408\u306f25%\u6e1b\u91cf\u3059\u308b\u3002<\/p>\n\n\n\n

\u25c6\u6295\u4e0e\u5468\u671f\u3068\u56de\u6570<\/h3>\n\n\n\n

21\u65e5\u5468\u671f\u30016 cycle\u3002Bev\u7dad\u6301\u7642\u6cd5\u3092\u884c\u3046\u5834\u5408\u3001Bev\u5358\u5264 16 cycle\u3092\u8ffd\u52a0\u3059\u308b\u3002<\/p>\n\n\n\n

\u25c6\u6295\u4e0e\u9806\u3068\u6295\u4e0e\u91cf<\/h3>\n\n\n\n
Rp<\/strong><\/td>\u6297\u304c\u3093\u5264<\/strong><\/td>\u6295\u4e0e\u91cf<\/strong><\/td>\u6295\u4e0e\u6642\u9593<\/strong><\/td>\u6295\u4e0e\u65e5<\/strong><\/td><\/tr>
1<\/td>PTX<\/td>175 mg\/m2<\/td>3 h<\/td>Day 1<\/td><\/tr>
2<\/td>CBDCA<\/td>AUC = 5\uff08or 6\uff09<\/td>1 h<\/td>Day 1<\/td><\/tr>
3<\/td>\uff08Bev\uff09<\/td>15 mg\/kg<\/td>90-30 min<\/td>Day 1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

<\/p>\n\n\n\n

\u25c6\u305d\u306e\u4ed6\u306e\u6295\u4e0e\u65b9\u6cd5<\/h3>\n\n\n\n

Dose dense TC\u7642\u6cd5<\/h4>\n\n\n\n
Rp<\/strong><\/td>\u6297\u304c\u3093\u5264<\/strong><\/td>\u6295\u4e0e\u91cf<\/strong><\/td>\u6295\u4e0e\u6642\u9593<\/strong><\/td>\u6295\u4e0e\u65e5<\/strong><\/td><\/tr>
1<\/td>PTX<\/td>80 mg\/m2<\/td>3 h<\/td>Day 1\u3001Day 8\u3001Day 15<\/td><\/tr>
2<\/td>CBDCA<\/td>AUC = 6<\/td>1 h<\/td>Day 1<\/td><\/tr>
3<\/td>\uff08Bev\uff09<\/td>15 mg\/kg<\/td>90-30 min<\/td>Day 1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

21\u65e5\u5468\u671f\u30016 cycle\u3002Bev\u7dad\u6301\u7642\u6cd5\u3092\u884c\u3046\u5834\u5408\u3001Bev\u5358\u5264 16 cycle\u3092\u8ffd\u52a0\u3059\u308b\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

Weekly TC\u7642\u6cd5\u2460<\/h4>\n\n\n\n
Rp<\/strong><\/td>\u6297\u304c\u3093\u5264<\/strong><\/td>\u6295\u4e0e\u91cf<\/strong><\/td>\u6295\u4e0e\u6642\u9593<\/strong><\/td>\u6295\u4e0e\u65e5<\/strong><\/td><\/tr>
1<\/td>PTX<\/td>80 mg\/m2<\/td>3 h<\/td>Day 1\u3001Day 8\u3001Day 15<\/td><\/tr>
2<\/td>CBDCA<\/td>AUC = 2<\/td>1 h<\/td>Day 1\u3001Day 8\u3001Day 15<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

21\u65e5\u5468\u671f\u30016 cycle\u3002<\/p>\n\n\n\n

Weekly TC\u7642\u6cd5\u2461<\/h4>\n\n\n\n
Rp<\/strong><\/td>\u6297\u304c\u3093\u5264<\/strong><\/td>\u6295\u4e0e\u91cf<\/strong><\/td>\u6295\u4e0e\u6642\u9593<\/strong><\/td>\u6295\u4e0e\u65e5<\/strong><\/td><\/tr>
1<\/td>PTX<\/td>60 mg\/m2<\/td>1 h<\/td>Day 1\u3001Day 8\u3001Day 15<\/td><\/tr>
2<\/td>CBDCA<\/td>AUC = 2<\/td>1 h<\/td>Day 1\u3001Day 8\u3001Day 15<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u6bce\u9031\u6295\u4e0e\u300218\u9031\u9593\u6295\u4e0e\u3002<\/p>\n\n\n

\u62d9\u8457\u300e\u5a66\u4eba\u79d1\u304c\u3093\u306e\u5206\u5b50\u75c5\u7406\u5b66\u3068\u6cbb\u7642\u30ec\u30b8\u30e1\u30f3\u300f<\/a>\u3082\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/h5><\/div><\/div>\n\n\n
\u5375\u5de3\u304c\u3093\u306b\u4f7f\u3046\u85ac\u7269\u7642\u6cd5\u30ec\u30b8\u30e1\u30f3<\/h5>\r\n