{"id":1102,"date":"2022-03-22T21:45:00","date_gmt":"2022-03-22T12:45:00","guid":{"rendered":"https:\/\/obgyn.jp\/?p=1102"},"modified":"2022-05-10T05:59:00","modified_gmt":"2022-05-09T20:59:00","slug":"gy004","status":"publish","type":"post","link":"https:\/\/obgyn.jp\/?p=1102","title":{"rendered":"\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\u611f\u53d7\u6027\u518d\u767a\u5375\u5de3\u764c\u306b\u5bfe\u3059\u308b PARP inhibitor \u3068\u5316\u5b66\u7642\u6cd5\u306e\u6bd4\u8f03"},"content":{"rendered":"\n<p>Olaparib \u306f PARP inhibitor \u3067\u3042\u308b\u3002Cediranib \u306f VEGFR \u963b\u5bb3\u85ac\u3067\u3042\u308b\u3002\u3044\u305a\u308c\u3082\u7d4c\u53e3\u85ac\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35290101\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">NRG-GY004<\/a> \u306f\u3001\u6700\u7d42\u306e\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\u6295\u4e0e\u5f8c6\u30f6\u6708\u4ee5\u4e0a\u7d4c\u904e\u3057\u3066\u518d\u767a\u3057\u305f\u5375\u5de3\u764c\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c3\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u3042\u308b\u3002\u5316\u5b66\u7642\u6cd5\uff08TC \u7642\u6cd5\u3001GC \u7642\u6cd5\u3001PLD-C \u7642\u6cd5\uff09\u7fa4\u3068\u3001Olaparib \u7fa4\u3042\u308b\u3044\u306f Olaparib+Cediranib \u7fa4\u3092\u6bd4\u8f03\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u7d50\u679c\u3001Olaparib \u7fa4\u3082 Olaparib+Cediranib \u7fa4\u3082\u3044\u305a\u308c\u3082\u5316\u5b66\u7642\u6cd5\u7fa4\u3068 PFS \u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p><em>BRCA<\/em> germline mutation \u304c\u3042\u308b\u5834\u5408\u3001Olaparib+Cediranib \u7fa4\u306f\u5316\u5b66\u7642\u6cd5\u7fa4\u3088\u308a\u3082\u6709\u610f\u306b PFS \u304c\u9577\u304b\u3063\u305f\u3002Olaparib \u7fa4\u306f\u5316\u5b66\u7642\u6cd5\u7fa4\u3068\u6709\u610f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p><em>BRCA<\/em> germline mutation \u304c\u306a\u3044\u5834\u5408\u3001Olaparib+Cediranib \u7fa4\u306f\u5316\u5b66\u7642\u6cd5\u7fa4\u3068 PFS \u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002Olaparib \u7fa4\u3088\u308a\u5316\u5b66\u7642\u6cd5\u7fa4\u306e\u65b9\u304c\u6709\u610f\u306b PFS \u304c\u9577\u304b\u3063\u305f\u3002<\/p>\n\n\n<h5>\u512a\u8d8a\u6027\u8a66\u9a13\u3001\u975e\u52a3\u6027\u8a66\u9a13\u3001\u540c\u7b49\u6027\u8a66\u9a13\u306e\u8aad\u307f\u65b9\u306f\u3001\u62d9\u8457<a href=\"https:\/\/amzn.to\/33ges1L\" target=\"_blank\">\u300e\u5a66\u4eba\u79d1\u304c\u3093\u306e\u5206\u5b50\u75c5\u7406\u5b66\u3068\u6cbb\u7642\u30ec\u30b8\u30e1\u30f3\u300f<\/a>\u3067\u56f3\u89e3\u3057\u3066\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002<\/h5>","protected":false},"excerpt":{"rendered":"<p>\u7b2c3\u76f8\u81e8\u5e8a\u8a66\u9a13 NRG-GY004 \u306e\u7d50\u679c\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[23,38],"class_list":["post-1102","post","type-post","status-publish","format-standard","hentry","category-obstetrics-gynecology","tag-ovca","tag-phase3"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/obgyn.jp\/index.php?rest_route=\/wp\/v2\/posts\/1102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/obgyn.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/obgyn.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/obgyn.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/obgyn.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1102"}],"version-history":[{"count":5,"href":"https:\/\/obgyn.jp\/index.php?rest_route=\/wp\/v2\/posts\/1102\/revisions"}],"predecessor-version":[{"id":1168,"href":"https:\/\/obgyn.jp\/index.php?rest_route=\/wp\/v2\/posts\/1102\/revisions\/1168"}],"wp:attachment":[{"href":"https:\/\/obgyn.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/obgyn.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/obgyn.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}